Jackson grew up in Detroit with seven siblings and parents who were both pastors. He credits his sense of humor to both his father and his life straddling the fence between suburbia and the inner city.
After Brandon's performances at New York City's "Showtime at the Apollo" and BET's Comicview (1992), the 19-year-old actor/comedian was cast in his first major movie role as Bow Wow's (X) best friend, "Junior", in Roll Bounce (2005). He won Black Reel's 2006 Best Breakthrough Performance award for his performance.
Jackson starred opposite NBA basketball superstar Kevin Durant in Thunderstruck (2012) and'Martin Lawrence (I)' in the third incarnation of the highly profitable Big Mommas: Like Father, Like Son (2011) franchise released by Fox in 2011. He played Lawrence's son and the two went undercover to solve a murder. Jackson is perhaps best known as Alpha Chino from the high- concept runaway hit Tropic Thunder (2008). Jackson received rave reviews for his role as the satyr Grover Underwood, the best friend and protector of Percy Jackson & the Olympians: The Lightning Thief (2010). Brandon co-stars in both Hulu's original series Deadbeat(2014) and Showtimes's "Californication" (2008).